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The difference between synchronous and asynchronous postback is as follows: • Asynchronous postback renders only the part of the page which is needed; while, synchronous postback renders the entire page in a postback. • Asynchronous postback executes only one postback at a time, that is, if you have two buttons doing asynchronous postback, the actions are executed one by one; while, synchronous postback invoke all the actions at a time. • Asynchronous postback only changes the update panel that invoke the postback; while, synchronous postback changes the entire page.