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When should AJAX NOT be used?

AJAX should not be used for critical data and transactions to avoid security breaches and to avoid situations where the page doesn't work as expected because javascript is not supported or is blocked.

If the page is expected to be shown in a search engine like Google. Since Web crawlers don't execute javascript code.

If the browser does not support JavaScript.

If security is a big concern in the application; Since Ajax allows end user to see half of what's being sent to the server.